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Medycyna Doświadczalna i Mikrobiologia 2012, 64(1): 73-78

Występowanie przeciwciał klasy IgG dla wirusa odry w surowicach osób w różnym wieku
[Presence of IgG class antibodies anti -measles virus in sera of subjects in different age]

Agnieszka Częścik, Milena Dunal, Agnieszka Trzcińska, Joanna Siennicka

Streszczenie

W pracy przedstawiono wyniki badań występowania przeciwciał klasy IgG swoistych dla wirusa odry w surowicach osób szczepionych i nieszczepionych przeciwko odrze, które miały na celu dokonanie doboru grupy do badań dotyczących pamięci immunologicznej.

Abstract

Introduction: The increase of measles incidence in Poland was recently observed. Furt­hermore, the analysis of routine serological tests performed in the Department of Virology, NIPH-NIH revealed, that nearly half of young people (20-30 years old) have no antibodies against measles virus. The paper presents results of IgG specific for measles virus prevalence in the sera of vaccinated and unvaccinated subjects, which aimed to make the selection of groups for immunological memory research. Methods: Total of 100 persons were examined based on results of determination of the presence of IgG anti-MeV: 26 people born before and 74 born after 1972 year. From this group, 55 participants were selected for further study and divided into 3 groups 1) subje­cts born before 1972, unvaccinated against measles and seropositive as a result of natural infection, 2) subjects born after 1972, vaccinated against measles but seronegative or with traces of anti-MeV IgG presence, 3) subjects born after 1972 seropositive due to vaccination. Selected persons are subject to further examinations include determination the number of leukocytes and lymphocytes profile.Results: The level of anty-MeV IgG antibodies in subjects after natural infection was sig­nificantly higher compared to levels obtained by vaccinations. No significant differences in the immunological parameters which could influence on immune response were observed.Conclusions: Obtained results lead to search other factors that may affect the weak po­stvaccinal humoral response.

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