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Medycyna Doświadczalna i Mikrobiologia 2010, 62(2): 119-126

SZCZEPY ACINETOBACTER BAUMANNII OPORNE NA KARBAPENEMY
[CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII STRAINS]

T. Bogiel, J. Kwiecińska-Piróg, K. Jachna-Sawicka, E. Gospodarek

Streszczenie

Przeprowadzono analizę retrospektywną szczepów Acinetobacter baumannii opornych na imipenem i/lub meropenem izolowanych w latach 2007-2009 z materiału od chorych leczonych w Szpitalu Uniwersyteckim nr 1 im. dr. A. Jurasza w Bydgoszczy. W okresie objętym analizą od 113 chorych izolowano 166 szczepów A. baumannii o fenotypie oporności na karbapenemy. Odnotowano w kolejnych latach wzrost odsetka szczepów opornych na imipenem i spadek - szczepów opornych na meropenem.

Abstract

A. baumannii rods are opportunistic pathogens responsible generally for nosocomial infections. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to evaluate the frequency of isolation and susceptibility to antibiotics of resistant to imipenem and/or meropenem A. baumannii strains isolated between 2007 and 2009 from patients of University Hospital of dr A. Jurasz Collegium Medicum
of L. Rydygier in Bydgoszcz Nicolaus Copernicus University in Toruń. Study shows increasing frequency of isolation that type of strains from 4 in 2007 to 95 in 2008 and 67 in 2009. Percentage of imipenem-resistant isolates raised to 27,6% in 2008 and 31,0% in 2009. Meropenem-resistant A. baumannii isolates frequency changed from 2,1% in 2007 to 31,2% and 34,6%, in 2008 and 2009,
respectively. The majority of strains were obtained from patients of the Intensive Care Units and surgery
clinics. Examined A. baumannii strains were generally isolated from bronchoalveolar lavage (25,3%)
and wound (18,1%) or throat (12,0%) swabs samples. The isolates demonstrated full resistance to
norfloxacin, ciprofloxacin, and chloramphenicol. Ampicillin/sulbactam (24,8%), tobramycin (8,1%)
and colistin (1,5%) presented the highest in vitro activity against isolated strains.

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