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Medycyna Doświadczalna i Mikrobiologia 2009, 61(4): 367-374

OCENA AKTYWNOŚCI DORIPENEMU WOBEC PAŁECZEK Z RODZAJÓW PSEUDOMONAS SP. I ACINETOBACTER SP.
[ACTIVITY OF DORIPENEM AGAINST PSEUDOMONAS SPP. AND ACINETOBACTER SPP. RODS]

T. Bogiel, A. Deptuła, E. Gospodarek

Streszczenie.

Przeprowadzono analizę aktywności doripenemu - nowego antybiotyku z grupy karbapenemów wobec szczepów pałeczek niefermentujących izolowanych z materiału pobranego od pacjentów Szpitala Uniwersyteckiego nr 1 w Bydgoszczy. Ogółem oznaczono lekowrażliwość 176 (74,9%) szczepom Pseudomonas sp. i 59 (25,1%) szczepom Acinetobacter sp. Odsetek szczepów opornych na doripenem był wyższy w przypadku pałeczek Acinetobacter (39,0%) w porównaniu z Pseudomonas (28,4%).

Abstract.

Doripenem, the newest carbapenem was approved in 2008 by the European Medicines Agency for the treatment of complicated intra-abdominal infections and complicated urinary tract infections. Its spectrum of activity is similar to that of meropenem and imipenem/cilastatin. The aim of this study was to compare in vitro activity of doripenem against nonfermentative Gram-negative rods. A total of 235 strains of Pseudomonas spp. (74,9%) and Acinetobacter spp. (25,1%) were included into the study. Strains were isolated in The Department of Clinical Microbiology of the University Hospital No 1 in Bydgoszcz and identified using ID GN tests (bioMérieux). To determine susceptibility to doripenem and other carbapenems disc-diffusion method was applied. Percentage of doripenem resistant strains reached 28,4% and 39,0% for Pseudomonas spp. and Acinetobacter spp, respectively. All doripenem sensitive or intermediate Acinetobacter spp. strains were simultaneously sensitive to imipenem and meropenem. Activity of imipenem and meropenem among doripenem resistant Acinetobacter spp. were represented by 60,9% and 56,5% strains, respectively. Activity of imipenem and meropenem among doripenem resistant Pseudomonas spp. strains were represented by 12,0% and 18,0%, respectively. Occurence of one doripenem sensitive Pseudomonas spp. strain simultaneously resistant to imipenem and meropenem was observed.

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